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To continue with the HIV/AIDS example, the agency might develop standards for testing the sensitivity and specificity of HIV diagnostic kits, then use those standards in reviewing kits that were submitted for approval What Biologics uniquely brought with it from the NIH was a tradition of doing the other kind of research Another fundamental aspect of science also has to be kept in mind Drugs and medical research are getting ever more complex Back in the 1970s, most medicines were derived from natural microorganisms, discovered by painstakingly analyzing, testing and tweaking samples of soil, sludge, mold, ground-up plants, and other exotic bits of nature The resulting drugs were mass market products, one-size-fits-all drugs for all people with high cholesterol or all people with arthritis They were aimed at the broadest possible audience in order to bring in the drug companies goal of $500 million or more in sales each year.

42 700 80 300

But the advent of genetic engineering in the 1980s, the decoding of the human genome in 2000, and other advanced techniques of biotechnology opened the door to much more complicated and finely targeted molecules, both chemical and biological In theory, the new disciplines of genomics and proteomics (the study of proteins) could draw a veritable road map to the causes of disease By comparing the genetic sequences in patients who have a particular disease with those who do not, so the assumption goes, researchers can look for the precise mutation that marks the presence of the disease Then they can craft a molecule that will latch onto a receptor on the troublemaking cell, fiddle with its function, and halt the progress of the disease or, alternatively, spur a cell to churn out more of a beneficial protein.

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They should even be able to target their molecules to the smallest subset of patients with a particular strain of the disease a torrent of Erbituxes and Iressas and Oncophages And if the traditional Big Pharma compa-.

The authors have tested whether several existing cryptanalytic techniques when applied to Rijndael can recover die key with a work factor less than exhaustive key trial, and Rijndael has been exposed to a careful scrutiny by outside cryptanalysts.

26. The ODE is 4y Thus y y 4.25y 50.5 cos 3t. The steady-state solution is obtained by the method of undetermined coefficients: yp 4.8 sin 3t 7.6 cos 3t. 4.8 sin 3t. From this general solution Hence 0 2B 14.4) 27y 3 4.8 2.8. 0. A 17.6 4y 17y 202 cos 3t.

= 0,

company thought it was safer not to be specific) Bob Ehrlich, in one of his weekly online columns, called the FDA s complaints about Novartis s Digger the Dermatophyte spot a case of stretching their interpretation of the law too far to find violations He said it was obvious that the toe fungus takes months, not 60 seconds, to clear up In a consumer [nondrug] ad you can make wild allusions to a guy driving a car through space The FDA doesn t want that This implies that cars can fly It is unsafe for people to drive their cars off a cliff I swear that s what you d get back, Michael Myers, the Saratoga Springs advertising executive, said contemptuously By virtually all accounts, there were far more clashes between industry and the FDA in the early years.

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